Daniel F. Brown, MD, MBA

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Daniel F. Brown, MD, MBA

Daniel F. Brown, MD, MBA
Chair, Department of Pathology and Laboratory Medicine; Medical Director; Chief, Section of Neuropathology

Dr. Daniel Brown is Chair of the Department of Pathology and Laboratory Medicine and Chief, Section of Neuropathology, Lehigh Valley Health Network. He also serves as Medical Director of Health Network Laboratories (HNL). Dr. Brown is the region’s only board-certified neuropathologist. He received his medical degree from Upstate Medical University, Syracuse, NY, and his MBA from the Isenberg School of Management at the University of Massachusetts, Amherst. He completed his anatomic pathology residency and neuropathology fellowship at the University of Texas Southwestern Medical Center, Dallas, TX, and he is a Diplomate of the American Board of Pathology, with combined board-certification in anatomic pathology and neuropathology.

Dr. Brown’s clinical expertise includes CNS tumor diagnosis, muscle and nerve pathology, and test utilization management. His research interests include the overlap of Alzheimer’s disease and Parkinson’s disease, and he has authored numerous original research articles, reviews and book chapters.


A Human Monoclonal IgG That Binds Aβ Assemblies and Diverse Amyloids Exhibits Anti-Amyloid Activities In Vitro and In Vivo
Yona Levites1, Brian O'Nuallain2, Rama Devudu Puligedda3, Tomas Ondrejcak4, Sharad P. Adekar3, Cindy Chen3, Pedro E. Cruz1, Awilda M. Rosario1, Sallie Macy5, Alexandra J. Mably2, Dominic M. Walsh2, Ruben Vidal6, Alan Solomon5, Daniel Brown7, Michael J. Rowan4, Todd E. Golde1, and Scott K. Dessain3
The Journal of Neuroscience, 22 April 2015, 35(16): 6265-6276; doi: 10.1523/JNEUROSCI.5109-14.2015 Abstract Full Text (PDF)

Radiation-induced tumor after stereotactic radiosurgery for an arteriovenous malformation: case report.
Berman EL, Eade TN, Brown D, Weaver M, Glass J, Zorman G, Feigenberg SJ.
Neurosurgery. 2007 Nov;61(5):E1099; discussion E1099.PMID: 18091259

Lethal vertebral artery dissection in pregnancy: a case report and review of the literature.
Tuluc M, Brown D, Goldman B.
Arch Pathol Lab Med. 2006 Apr;130(4):533-5.PMID: 16594746

Fatal myositis due to the microsporidian Brachiola algerae, a mosquito pathogen.
Coyle CM, Weiss LM, Rhodes LV 3rd, Cali A, Takvorian PM, Brown DF, Visvesvara GS, Xiao L, Naktin J, Young E, Gareca M, Colasante G, Wittner M.
N Engl J Med. 2004 Jul 1;351(1):42-7. No abstract available.PMID: 15229306 Free PMC Article

Progressive supranuclear palsy with dementia: cortical pathology.
Bigio EH, Brown DF, White CL 3rd.
J Neuropathol Exp Neurol. 1999 Apr;58(4):359-64.PMID: 10218631

Neocortical synapse density and Braak stage in the Lewy body variant of Alzheimer disease: a comparison with classic Alzheimer disease and normal aging.
Brown DF, Risser RC, Bigio EH, Tripp P, Stiegler A, Welch E, Eagan KP, Hladik CL, White CL 3rd.
J Neuropathol Exp Neurol. 1998 Oct;57(10):955-60.PMID: 9786245

Systemic calciphylaxis associated with massive gastrointestinal hemorrhage.
Brown DF, Denney CF, Burns DK.Arch Pathol Lab Med. 1998 Jul;122(7):656-9.PMID: 9674549

Correlation of bcl-2, p53, and MIB-1 expression with ependymoma grade and subtype.
Rushing EJ, Brown DF, Hladik CL, Risser RC, Mickey BE, White CL 3rd.
Mod Pathol. 1998 May;11(5):464-70.PMID: 9619600

Supratentorial giant cell ependymoma: a case report.
Brown DF, Chason DP, Schwartz LF, Coimbra CP, Rushing EJ.
Mod Pathol. 1998 Apr;11(4):398-403.PMID: 9578093

Hormone receptor immunoreactivity in hemangioblastomas and clear cell renal cell carcinomas.
Brown DF, Dababo MA, Hladik CL, Eagan KP, White CL 3rd, Rushing EJ.
Mod Pathol. 1998 Jan;11(1):55-9.PMID: 9556423

Neuropathologic evidence that the Lewy body variant of Alzheimer disease represents coexistence of Alzheimer disease and idiopathic Parkinson disease.
Brown DF, Dababo MA, Bigio EH, Risser RC, Eagan KP, Hladik CL, White CL 3rd.
J Neuropathol Exp Neurol. 1998 Jan;57(1):39-46.PMID: 9600196

Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas.
Brown DF, Gazdar AF, White CL 3rd, Yashima K, Shay JW, Rushing EJ.
J Neuropathol Exp Neurol. 1997 Dec;56(12):1349-55.PMID: 9413283

Rosenthal fibers and eosinophilic granular bodies in a classic acoustic schwannoma.
Brown DF, Rushing EJ.
Arch Pathol Lab Med. 1997 Nov;121(11):1207-9.PMID: 9372750

Expression of telomerase RNA component correlates with the MIB-1 proliferation index in ependymomas.
Rushing EJ, Yashima K, Brown DF, White CL 3rd, Shay JW, Risser RC, Gazdar AF.
J Neuropathol Exp Neurol. 1997 Oct;56(10):1142-6.PMID: 9329458

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